Psoriasis afflicts millions of people worldwide, but treatments are limited to small molecules like steroids, which can cause skin thinning and lose their effectiveness over time. Medical researchers have circumvented those problems by using a topical ionic liquid to effectively deliver an RNA-based therapy directly into the skin of mice with psoriasis, which reduced multiple psoriasis-related gene products as well as redness and inflammation, resolving the longstanding challenge of delivering nucleic acids into cells.