Researcher found that exposed individuals with confirmed TB infection — i.e. a positive skin or blood test — should receive priority treatment in settings with a low prevalence of the disease, regardless of their age. However, in high-burden settings, all exposed individuals should be considered for preventative treatment, even without a confirmed infection. This strategy can help end the tuberculosis epidemic and support global public health efforts to reduce TB mortality by 95 percent by 2035 (from 2015 estimates).