Month: May 2020

May 08 2020

Medicine, Biotech, Research

A Mitochondrial Signal of Sarcopenia and Frailty Found in Small Extracellular Vesicles

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Much of the signaling that passes between cells is carried in extracellular vesicles, small membrane-wrapped packages of molecules. There are numerous classes of such vesicle, varying in size, such as...

May 08 2020

Daily News

Improving Transplanted Stem Cell Function via Tethered Signal Molecules

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The field of biotechnology is churns with inventive technology demonstrations; this is an era of creativity, unleashed by a rapid advance in knowledge and capabilities. Here, researchers are presented with...

May 08 2020

Daily News

Towards an Amyloid-β Sequestering Nanoparticle to Block Protein Aggregation

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Researchers here report on development of a nanoparticle that sweeps up the amyloid-β associated with Alzheimer’s disease, preventing it from forming aggregates. When stuck to the nanoparticle, amyloid-β will not...

May 07 2020

Medicine, Biotech, Research

Another Example of a Galactose-Conjugated Senolytic Prodrug

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Killing cells is easy. Killing only the cells that you want to kill, while leaving all other cells untouched, is very much more challenging. The ability to do this is...

May 07 2020

Daily News

Towards Ionomic Aging Clocks

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The ionome is the elemental composition of a tissue, organ, or individual. This composition changes over the course of aging, and may do so in ways that allow the production...

May 07 2020

Daily News

Rapamycin Slows Age-Related Periodontitis in Mice

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The mTOR inhibitor rapamycin slows the progression of aging in mice. The may largely be a result of upregulated autophagy, as is the case for many other means of slowing...

May 06 2020

Medicine, Biotech, Research

α-synuclein Aggregation Impairs Autophagy in Brain Tissue

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Age-related neurodegeneration is characterized by the aggregation of a small number of proteins, including α-synuclein, that can become altered in a manner that encourages other molecules of the same protein...

May 06 2020

Daily News

Hydrogen Treatment Modestly Dampens Oxidative Stress in Nematodes

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Hydrogen can scavenge free radical molecules, and thus act as a form of antioxidant. Researchers here demonstrate that in action in nematode worms. Excessive levels of free radicals such as...

May 06 2020

Daily News

Reducing Neuroinflammation Slows Onset of Neurodegeneration in Animal Models

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Alzheimer’s disease is strongly driven by chronic inflammation in brain tissue. Studies in which senescent, inflammatory microglia are removed from the brain strongly suggests this to be the case in...

May 05 2020

Medicine, Biotech, Research

What is the Degree of Synergy Between Different Longevity-Associated Mechanisms?

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The degree to which interventions targeting different mechanisms associated with longevity might stack or synergize to produce greater gains is a woefully understudied topic. Study of synergies between treatment approaches...