Category: Medicine, Biotech, Research

Oct 05 2026

Medicine, Biotech, Research

Accelerated Epigenetic Aging Correlates with Later Loss of Memory Function

by Consultant

No Comments

Aging clocks have yet to fulfill their promise, which is to produce a robust measure of biological aging that can be used to rapidly assess the results of potential therapies...

Oct 02 2026

Medicine, Biotech, Research

A Conservative View of the Geroscience Endeavor

by Consultant

No Comments

An archly conservative viewpoint links establishment academia (“this thing you are doing has not yet been proven beyond all doubt to work”) to the thought leadership of Big Pharma (“this...

Oct 01 2026

Medicine, Biotech, Research

Don’t View mTOR as a Single Pharmaceutical Target, as Context Matters

by Consultant

No Comments

Of the many varied approaches to mimic some of the beneficial metabolic response to calorie restriction, mTOR inhibition is arguably the most well studied. Countless animal studies have been conducted,...

Sep 30 2026

Medicine, Biotech, Research

PD-L1 Blockade in the Brain Restores Measures of Glial Cell Function

by Consultant

No Comments

PD-L1 found on the surface of cells is a well known immune checkpoint protein. When it binds to the receptor PD-1 found on the surface of T cells and B...

Sep 28 2026

Medicine, Biotech, Research

A Unified Cause for Loss of Type 1 Dendritic Cell Function in Aging, Cancer, and Chronic Infection

by Consultant

No Comments

Type 1 conventional dendritic cells are a subclass of dendritic cell known to be an important component of the immune response to pathogens and cancerous cells, particularly focused on stimulating...

Sep 27 2026

Medicine, Biotech, Research

Proposing a Novel Set of Proxy Measures of Aging Rate

by Consultant

No Comments

It is well understood in the aging research community that the lack of a useful, consensus measure of biological age or pace of biological aging is a considerable hindrance to...

Sep 25 2026

Medicine, Biotech, Research

cGAS Knockout Reduces Cellular Senescence in Aged Killifish, But Does Not Extend Life

by Consultant

No Comments

The cGAS protein is a sensor for mislocalized DNA in the cell cytoplasm, and responds by triggering STING, a regulator of the inflammatory response to damage and dysfunction. The cGAS-STING...

Oct 30 2020

Medicine, Biotech, Research

Towards Restoration of Mitophagy to Reverse Mitochondrial Dysfunction in Alzheimer’s Disease

by Consultant

No Comments

Mitochondria are the power plants of the cell, a herd of bacteria-like organelles responsible for packaging energy store molecules used to power the chemistry of life. With age, mitochondria become...

Oct 29 2020

Medicine, Biotech, Research

Another New Senolytic Prodrug is Demonstrated to Reverse Frailty and Cognitive Function in Old Mice

by Consultant

No Comments

Today’s open access paper reports on the use of a prodrug senolytic strategy to reverse aspects of aging in mice via the selective destruction of senescent cells. A prodrug is...

Oct 28 2020

Medicine, Biotech, Research

Wnt Signaling in Neurogenesis and the Aging of the Brain

by Consultant

No Comments

The Wnt signaling pathway is found somewhere in the midst of the exceedingly complicated network of processes that regulate regeneration and stem cell function. This small slice of cellular biochemistry...