Month: August 2020

Aug 15 2020

Daily News

Mitochondrial Dysfunction in Monocytes of the Innate Immune System Contributes to Inflammaging

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Inflammaging is the name given to the constant activation of the immune system that occurs in older individuals. Inflammation is useful and necessary in the short term, for the destruction...

Aug 14 2020

Medicine, Biotech, Research

Reviewing Associations Between Physical Activity and Loss of Average Telomere Length with Age

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Telomeres are repeated DNA sequences at the ends of chromosomes. With each cell division a little telomere length is lost, and this is an important part of the countdown mechanism...

Aug 14 2020

Daily News

Exercise May Aid in Resisting Frailty and Cognitive Decline in Part via Effects on the Gut Microbiome

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The gut microbiome is influential on long-term health, and its quality declines with age. Microbial populations that produce beneficial metabolites such as butyrate or propionate decline in number, replaced by...

Aug 14 2020

Daily News

Should Rapamycin be Prescribed Ubiquitously as an Anti-Aging Supplement?

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Should rapamycin be prescribed ubiquitously as an anti-aging supplement? That is the question the authors of this commentary ask after a short overview of what is known of the beneficial...

Aug 13 2020

Medicine, Biotech, Research

Reducing LDL Cholesterol is the Wrong Target for Cardiovascular Disease

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When people say “cardiovascular disease” in the context of blood cholesterol, they mean atherosclerosis. This is the name given to the build up of fatty deposits that narrow and weaken...

Aug 13 2020

Daily News

Considering the Use of Lasers to Break Down Harmful Protein Aggregates

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It is possible to tailor the frequency of laser light to selectively disrupt the bonds or structure of particular arrangements of molecules – such as, say, the harmful protein aggregates...

Aug 13 2020

Daily News

A Fisetin Variant, CMS121, Slows Disease Progress in an Alzheimer’s Mouse Model

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The research materials here are of interest because fisetin has been shown to be a senolytic compound in mice, capable of selectively destroying harmful senescent cells. Other senolytics have reversed...

Aug 12 2020

Medicine, Biotech, Research

Telomerase Gene Therapy May Treat Fibrosis via a Reduced Burden of Cellular Senescence

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A number of research groups are quite enthusiastic about the prospects for telomerase gene therapy as a treatment for aging and numerous age-related diseases. This is based on more than...

Aug 12 2020

Daily News

Overexpression of VRK-1 Extends Life Span in Nematode Worms

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A great many approaches exist to slow aging in short-lived laboratory species such as nematodes, flies, and mice. The example here is an illustrative example, similar to dozens of other...

Aug 12 2020

Daily News

The Gut Microbiome Changes Shortly Before Death in Centenarians

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Extremely old people have such high mortality rates that studies such as this one here become practical, answering the question of how the gut microbiome changes in the final decline...