Category: Daily News

Jun 05 2020

Daily News

Exercise Increases Ubiquitination to Clear Damaged Proteins

by Consultant

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The ubiquitin-proteasome system is one of the ways in which cells remove damaged and unwanted proteins. Proteins are tagged with ubiquitin, which allows them to enter a proteasome and be...

Jun 05 2020

Daily News

Promoting Autophagy to Restore Function in the Aging Liver

by Consultant

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The processes of autophagy recycle damaged and unwanted structures and proteins in cells. Increased autophagy is involved in the beneficial response to calorie restriction and numerous other mild forms of...

Jun 04 2020

Daily News

Targeting the Failure of Mitophagy as a Basis for Treating Age-Related Disease

by Consultant

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Evidence strongly suggests that the global faltering of mitochondrial function throughout the body with advancing age has a lot to do with a decline in the effectiveness of mitophagy. Mitochondria...

Jun 04 2020

Daily News

The Role of Autophagy in the Beneficial Effects of Exercise

by Consultant

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Autophagy is the name given to a collection of processes responsible for recycling damaged or otherwise unwanted structures and proteins in the cell. With age, autophagy becomes less efficient. Many...

Jun 03 2020

Daily News

Antibodies that Target Toxic Amyloid-β Oligomers

by Consultant

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One possible expansion of present immunotherapies for Alzheimer’s disease is to more specifically track and target oligomeric forms of amyloid-β. Efforts to reduce amyloid-β in the brain have, after many...

Jun 03 2020

Daily News

Exercise Training Increases Capillary Density in a Mouse Model of Heart Failure

by Consultant

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Exercise is known to improve outcomes in heart failure patients, but there is a limit as to the data that can be obtained on mechanisms of action from human patients....

Jun 02 2020

Daily News

Longer Female Life Spans Vary Widely by Species and Likely Have Complex Roots

by Consultant

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In most species, including our own, females live longer than males. Why this is the case is likely one of those simple questions that lacks a simple answer. At the...

Jun 02 2020

Daily News

BCL-xL as a Longevity Gene

by Consultant

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BCL-xL is a mitochondrial protein that acts to suppress the programmed cell death response of apoptosis, and is overexpressed in some cancers, as well as in senescent cells. Thus small...

May 30 2020

Daily News

Visceral Fat Behaves Differently in Long-Lived Dwarf Mice

by Consultant

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A few varieties of dwarf mice exhibit considerable longevity. They are produced via forms of mutation that disable portions of growth hormone metabolism, such as via growth hormone receptor knockout....

May 30 2020

Daily News

Reviewing the Prospects for Nicotinamide Mononucleotide Supplementation to Raise NAD+ Levels and Improve Health

by Consultant

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A fair amount of effort is presently put towards the exploration of supplements derived from vitamin B3 compounds (nicotinamide, niacin, nicotinamide riboside) that act as precursors to enable the manufacture...