Category: Daily News

Oct 09 2020

Daily News

Klotho in Aging and the Failing Kidney

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Klotho is one of the few longevity-associated genes with robustly demonstrated effects in both directions: reduce its expression and life span is reduced, increase its expression and life span is...

Oct 09 2020

Daily News

An Example of the Beneficial Role of Senescence in Injury

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Researchers here provide an interesting demonstration of the beneficial role of transient cellular senescence in injury. Applying senolytics to selectively destroy senescent cells immediately following traumatic injury greatly worsens the...

Oct 08 2020

Daily News

Lef1 Enables Skin Regeneration Without Scarring in Mice

by Consultant

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To achieve regeneration without scarring is an important goal in the medical research community. Some species are capable of proficient regeneration of even whole limbs or internal organs, but mammalian...

Oct 08 2020

Daily News

Markers of Chronic Inflammation Correlate with Age-Related Loss of Muscle Mass and Strength

by Consultant

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Chronic inflammation is a sizable component of aging. The immune system becomes inappropriately overactive, disrupting its normal participation in tissue maintenance, and producing alterations in the signaling environment that change...

Oct 07 2020

Daily News

The More Time Spent with High Blood Cholesterol, the Greater the Lifetime Risk of Heart Disease

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Researchers here suggest that the processes of atherosclerosis, leading to the buildup of fatty deposits that narrow and weaken blood vessels, are cumulative over time. One of the risk factors...

Oct 07 2020

Daily News

Dopaminergenic Neurons Transplanted into Mouse Brains Integrate Into Neural Circuits and Improve Parkinson’s Symptoms

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Researchers here demonstrate that human dopaminergenic neurons, the class of cell lost in Parkinson’s disease, can integrate into neural circuits and improve motor function when transplanted into mice. The challenge...

Oct 06 2020

Daily News

Making the Leap from Mice to Humans in the Treatment of Aging

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This commentary makes the point that the development of interventions to slow and reverse aging is moving along at some pace in mice, the field expanding year after year, but...

Oct 06 2020

Daily News

Senolytics as an Arm of Regenerative Medicine for the Elderly

by Consultant

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Senolytic therapies are those that selectively destroy the senescent cells that accumulate in tissues with age. These cells secrete a potent mix of signals that produce chronic inflammation and degrade...

Oct 03 2020

Daily News

Insight into How Loss of Functional TDP-43 Contributes to ALS and Frontotemporal Dementia

by Consultant

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TDP-43 is one of a number of proteins that can misfold in ways that cause neurodegeneration, either via aggregation into solid deposits, or via a diminished amount of functional protein...

Oct 03 2020

Daily News

Fructose Metabolism in Alzheimer’s Disease

by Consultant

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The degree to which Alzheimer’s disease is a lifestyle condition is an interesting question. A good deal of research points to insulin resistance in the brain as important in the...