Category: Daily News

Oct 02 2020

Daily News

Ketone Body β-hydroxybutyrate Inhibits Inflammation to Reduce Alzheimer’s Pathology in a Mouse Model

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Ketosis is a response to low dietary intake of carbohydrates, and one of the mechanisms by which calorie restriction produces benefits to health and longevity. A ketogenic diet attempts to...

Oct 02 2020

Daily News

Visceral Fat Tissue is the Major Determinant of Mortality Due to Excess Body Weight

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It is the metabolic activity of visceral fat packed around abdominal organs that determines most of the harmful consequences of being overweight, not the subcutaneous fat deposits elsewhere in the...

Oct 01 2020

Daily News

Learning is Damaged Before Memory in the Progression to Clinical Alzheimer’s

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Researchers searching for better ways to assess the early progression towards clinical Alzheimer’s disease have established what looks like a decent way to measure loss of learning capability, a decline...

Oct 01 2020

Daily News

Cellular Senescence as a Mediator of Age-Related COVID-19 Severity

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Wherever we find the intersection of inflammation and aging, important in many age-related conditions, it has become the case that attention is drawn to the role of senescent cells. Senescent...

Sep 30 2020

Daily News

Parkinson’s Disease is Two Distinct Conditions with a Similar Outcome

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Some age-related and other diseases with formal definitions based on symptoms and late stage mechanisms are likely several distinct conditions that happen to converge on a similar end result. This...

Sep 30 2020

Daily News

Exosome Therapy Appears as Effective as Cell Therapy for Cardiac Regeneration

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Cells are logistically challenging and more expensive to work with in comparison to components of cell signaling such as proteins or extracellular vesicles. In cell therapies wherein the bulk of...

Sep 29 2020

Daily News

Upregulation of Mitophagy as an Approach to Treat Age-Related Disease

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Mitophagy is a cellular housekeeping process that removes damaged mitochondria. Mitochondria are the power plants of the cell, crucial in all tissues, but particularly so in the energy-hungry brain and...

Sep 29 2020

Daily News

Injection of Metformin Improves Cognitive Function in Old Mice to a Greater Degree than Oral Administration

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Researchers here note that delivering metformin via injection rather than the usual oral administration removes unwanted side-effects and better improves cognitive function in old mice. Near all testing of metformin...

Sep 26 2020

Daily News

A Discussion of Targeting the Mechanisms of Cardiovascular Aging

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This very readable open access paper discusses some of the mechanisms involved in cardiovascular aging. As for many such publications, and to my eyes at least, it leans too much...

Sep 26 2020

Daily News

Naringenin is a Senotherapeutic that Enhances Neurogenesis in Mice

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Researchers here evaluate the flavonoid naringenin for its ability to dampen the inflammatory signaling of senescent neural cells, particularly levels of TNF-α, and increase neurogenesis in mice. This increased neurogenesis...