Skincare

Sep 25 2020

Medicine, Biotech, Research

Rescuing Senescent Cells by Delivering New Mitochondria Sounds Like a Risky Proposition

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Mitochondria are effectively power plants, hundreds of these organelles per cell working to create the chemical energy store molecule adenosine triphosphate. Mitochondria are the descendants of ancient symbiotic bacteria, and...

Sep 25 2020

Daily News

Theorizing on Cosmic Radiation as an Accelerator of Aging via Cellular Senescence

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Researchers here suggest that some of the detrimental effects of prolonged space missions are mediated by an increased burden of senescent cells resulting from cosmic radiation exposure. Senescent cell accumulation...

Sep 25 2020

Daily News

Activated and Senescent Microglia as a Contributing Cause of Neurodegeneration

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Microglia are innate immune cells of the brain, responsible not just for destroying pathogens and errant cells, but also for clearing debris and assisting neurons in managing the connections of...

Sep 24 2020

Medicine, Biotech, Research

Medin Amyloid Aggregation with Age Causes Cerebral Vascular Dysfunction

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There are twenty or so different proteins in the body that can become altered in ways that cause them to aggregate into solid deposits known as amyloids, spreading and encouraging...

Sep 24 2020

Daily News

miR-192 in Extracellular Vesicles as a Negative Regulator of Inflammation in Old Tissues

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Chronic inflammation is a feature of aging; the immune system is persistently overactive, and this disrupts tissue function in numerous ways, contributing to the progression of age-related disease. There are...

Sep 24 2020

Daily News

Proposing an Approach to Obtain Human Data on Combined Interventions and Effects on Aging

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With the advent of epigenetic clocks that appear able to measure biological age, researchers are interested in putting these clocks to work on the assessment of interventions that might affect...

Sep 23 2020

Medicine, Biotech, Research

Reviewing the Clinical Evidence for NAD+ Upregulation

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I recently collaborated on a review paper covering the history of clinical work on upregulation of nicotinamide adenine dinucleotide (NAD) as an approach to therapy. This is of interest to...

Sep 23 2020

Daily News

Reducing Chronic Inflammation as Effective as Reducing Blood Cholesterol in Producing a Small Reversal of Atherosclerotic Lesions

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The study results here provide an interesting comparison between the strategies of lowering inflammation and lowering blood cholesterol for the treatment of atherosclerosis. Atherosclerosis is the name given to the...

Sep 23 2020

Daily News

Fasting Mimicking Diet Improves Chemotherapy Effectiveness and Reduces Side Effects

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The fasting mimicking diet emerged from efforts to better define the dose-response curve for beneficial effects resulting from a reduced calorie intake. Fasting is beneficial, calorie restriction is beneficial, but...

Sep 22 2020

Medicine, Biotech, Research

Mitochondrial Point Mutations Contribute to Female Reproductive Aging, and NAD+ Upregulation Attenuates These Consequences in Mice

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Today’s open access paper discusses the impact of mitochondrial DNA damage on female reproductive capabilities. Mitochondria are the power plants of the cell, a herd of hundreds of organelles responsible...