Skincare

Jun 20 2020

Medicine, Biotech, Research

Senescent Cardiomyocytes in Cardiovascular Disease

by Consultant

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Senescent cells accumulate in tissues throughout the body with age. Cells constantly become senescent as a result of wound healing, cancer suppression, the Hayflick limit on cellular replication, or damage...

Jun 20 2020

Daily News

CD9 Expression in Cellular Senescence and Atherosclerosis

by Consultant

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Cellular senescence is important in the progression of aging, and targeted elimination of senescent cells has been shown to reverse the course of many age-related conditions in animal studies. Atherosclerosis...

Jun 20 2020

Daily News

Regular Physical Activity Reverses Frailty in the Old

by Consultant

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There is considerable evidence for the proposition that older people engage in too little physical activity. Our modern societies of comfort and our engines of transport enable a sedentary lifestyle,...

Jun 19 2020

Medicine, Biotech, Research

Fitting Senescent Cells into a Modified Amyloid Cascade Hypothesis of Alzheimer’s Disease

by Consultant

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The amyloid cascade hypothesis is the earliest coherent view of the development of Alzheimer’s disease. In this view, the condition begins with the slow aggregation of amyloid-β over many years,...

Jun 19 2020

Daily News

Stiffening of the Extracellular Matrix Contributes to Age-Related Muscle Impairment

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In this interesting open access paper, the authors explore the contribution of changes in the extracellular matrix to the deterioration of muscle function that takes place with aging. The extracellular...

Jun 19 2020

Daily News

Repetitive Elements as a Transcriptomic Biomarker of Aging

by Consultant

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Retrotransposons are receiving more attention in the context of aging these days. They are the remnants of ancient viruses, capable of copying themselves around the genome. The mechanisms repressing this...

Jun 18 2020

Exercise, Featured, Fitness, Programs

Training zones – getting the BEST ROI on your exercise

by Consultant

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If you are anything like me, you hate wasting time and are looking for the best return on investment (ROI) on your exercise efforts. As a result, to drive my...

Jun 18 2020

Medicine, Biotech, Research

An Example to Illustrate Why Navitoclax is Not a Suitable Clinical Senolytic Drug

by Consultant

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Senolytic therapies are those that selectively destroy senescent cells. Cells that become senescent grow in size, cease to replicate, and generate a potent mix of molecules known as the senescence-associated...

Jun 18 2020

Daily News

Blood Pressure Control Increases Life Expectancy Even in the Most Frail Elderly People

by Consultant

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Chronically raised blood pressure, or hypertension, is highly damaging to tissues throughout the body. It is an important mechanism linking the molecular damage of aging to gross structural damage to...

Jun 18 2020

Daily News

Retraining the Immune System to Turn Off Autoimmunity

by Consultant

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This interesting study suggests that it may be possible to turn off many forms of autoimmunity by inducing tolerance, in a comparatively simple manner, to the specific fragment of a...