Skincare

May 05 2020

Daily News

The Ordering of Cholesterol Accumulation and Inflammatory Response in Foam Cell Formation

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The development of atherosclerotic lesions involves the dysfunction of macrophage cells. They are normally responsible for removing lipids from lesions and handing it off to HDL particles to be returned...

May 04 2020

Uncategorized

Gene defects linked to eczema, wheeze and nasal disease among babies

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A link has been discovered between a common gene defect and eczema, nasal blockage and wheeze among babies as young as six months, according to a new study. The research raises new questions about how soon in life these defects...

May 04 2020

Newsletters

Fight Aging! Newsletter, May 4th 2020

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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine....

May 02 2020

Medicine, Biotech, Research

Turning Navitoclax into a PROTAC Senolytic with a Better Safety Profile

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It is interesting to compare today’s open access paper on converting the senolytic drug navitoclax into a PROTAC with recent efforts to improve navitoclax by conjugation with galactose. In both...

May 02 2020

Daily News

Hearing Loss Impairs Synaptic Plasticity and Memory Function in Mice

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The brain makes use of sensory information in order to form memories. Loss of hearing has an impact on the aging brain, as suggested by the correlation between onset of...

May 02 2020

Daily News

Mechanisms of Neurodegeneration Interact to Contribute to Multiple Conditions

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The common neurodegenerative conditions are characterized by the aggregation of a few types of misfolded or otherwise altered proteins, harmful to cell and tissue function. Each form of protein aggregate...

May 01 2020

Self-Experimentation

Notes on Self-Experimentation with Sex Steroid Ablation for Regrowth of the Thymus

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I periodically publish thoughts on self-experiments that seem interesting and relevant to aging. Despite the influence of the quantified self movement, the broader self-experimentation community is largely terrible on matters...

May 01 2020

Daily News

Photobiomodulation to Enhance Mitochondrial Function as a Potential Therapy for Parkinson’s Disease

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There is evidence for near-infrared light to improve mitochondrial function, although exactly how it works, and how reliably it works, is far from settled. This wavelength of light penetrates tissue...

May 01 2020

Daily News

Adjusting Macrophage Polarization for Therapeutic Effects is not Straightforward

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The innate immune cells known as macrophages can adopt different packages of behaviors, known as polarizations, under different circumstances. The underlying reality is more a continuum than two clear categories,...

Apr 30 2020

Medicine, Biotech, Research

The Existence of Senolytics May Trigger the Shift Towards Targeting Root Causes of Disease

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It is sadly true that little medical research and development involves targeting the root causes of the treated condition. This is exactly why therapies largely fail in trials, and are...