Month: June 2020

Jun 26 2020

Daily News

Demonstrating a Senolytic Chimeric Antigen Receptor T Cell Therapy

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Chimeric antigen receptor (CAR) T cell therapies target specific surface features on other cells by providing T cells with a way to recognize that feature – the CAR. T cells...

Jun 26 2020

Daily News

Sedentary Behavior Raises the Risk of Cancer Mortality

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Living a sedentary lifestyle is known to be harmful to long term health, raising the risk of age-related disease and mortality. Researchers here show that a sedentary life specifically increases...

Jun 25 2020

Medicine, Biotech, Research

Nanoparticles Containing Cyclodextrins to Sequester Cholesterol Do Well in an Atherosclerosis Animal Model

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Cyclodextrins bind to cholesterol. This aspect of their biochemistry has been used by the Underdog Pharmaceuticals team to produce a cyclodextrin that binds the form of toxic oxidized cholesterol known...

Jun 25 2020

Daily News

Using the Metabolome to Produce an Aging Clock

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It has been a while now since the development of the first epigenetic clock, a weighted combination of DNA methylation sites that correlates tightly with chronological age. More interesting is...

Jun 25 2020

Daily News

Lower Socioeconomic Status Correlates with Faster Age-Related Decline

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There is a well-established web of correlations between life expectancy, wealth, intelligence, education, and social status. It is challenging to pick apart the underlying mechanisms, however, given demographic and epidemiological...

Jun 24 2020

Medicine, Biotech, Research

Cyclic Peptides to Remodel the Gut Microbiome by Suppressing Growth of Harmful Bacteria

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Research into the effects of the gut microbiome on health and aging is presently flourishing. Scientists are identifying meaningful changes in microbial populations that take place with age, as well...

Jun 24 2020

Daily News

The Challenge of Cellular Senescence in Mesenchymal Stem Cell Therapy

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The accumulation of senescent cells in tissues throughout the body is a cause of aging, but it is also a phenomenon that occurs in cell cultures. Senescent cells do not...

Jun 24 2020

Daily News

The Immune Response to Tumors Changes with Age

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The interaction between the immune system and tumor is meaningfully different in young and old individuals. The aging of the immune system makes near everything worse in health and physiology....

Jun 23 2020

Medicine, Biotech, Research

Reviewing the Role of the Immune System in Clearance of Senescent Cells

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Cells in the body become senescent constantly, in response to reaching the Hayflick limit on replication, to DNA damage, to a toxic local environment, to injury. A senescent cell grows...

Jun 23 2020

Daily News

A Central Role for p53 in Osteoporosis?

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Osteoporosis is the name given to the advanced stages of the characteristic age-related loss of bone strength and density. Bone tissue is constantly remodeled, created by osteoblasts and broken down...