Author: Consultant

Sep 23 2020

Medicine, Biotech, Research

Reviewing the Clinical Evidence for NAD+ Upregulation

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I recently collaborated on a review paper covering the history of clinical work on upregulation of nicotinamide adenine dinucleotide (NAD) as an approach to therapy. This is of interest to...

Sep 23 2020

Daily News

Fasting Mimicking Diet Improves Chemotherapy Effectiveness and Reduces Side Effects

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The fasting mimicking diet emerged from efforts to better define the dose-response curve for beneficial effects resulting from a reduced calorie intake. Fasting is beneficial, calorie restriction is beneficial, but...

Sep 23 2020

Daily News

Reducing Chronic Inflammation as Effective as Reducing Blood Cholesterol in Producing a Small Reversal of Atherosclerotic Lesions

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The study results here provide an interesting comparison between the strategies of lowering inflammation and lowering blood cholesterol for the treatment of atherosclerosis. Atherosclerosis is the name given to the...

Sep 22 2020

Daily News

Calorie Restriction Improves Intestinal Stem Cell and Barrier Function in Old Mice

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The practice of calorie restriction improves many measures of health, and extends life meaningfully in short lived species such as mice. Unfortunately, while calorie restriction improves health in much the...

Sep 22 2020

Daily News

Evidence for Chronic Inflammation to be a Significant Factor in Age-Related Hearing Loss

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Hearing loss is a prevalent problem with age, the result of loss of sensory hair cells of the inner ear, or as seems more likely in recent years, damage to...

Sep 22 2020

Medicine, Biotech, Research

Mitochondrial Point Mutations Contribute to Female Reproductive Aging, and NAD+ Upregulation Attenuates These Consequences in Mice

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Today’s open access paper discusses the impact of mitochondrial DNA damage on female reproductive capabilities. Mitochondria are the power plants of the cell, a herd of hundreds of organelles responsible...

Sep 21 2020

Newsletters

Fight Aging! Newsletter, September 21st 2020

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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine....

Sep 19 2020

Medicine, Biotech, Research

Higher Temperature Slows Osteoporosis, an Effect Mediated by Polyamine Produced by Gut Microbes

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Osteoporosis is the name given to the characteristic age-related loss of bone mass and strength. The extracellular matrix of bone tissue is constantly remodeled, created by osteoblasts and broken down...

Sep 19 2020

Daily News

Long Term mTORC1 Inhibition Slows Muscle Aging in Mice via Preservation of Neuromuscular Junctions

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Sarcopenia is the name given to the characteristic loss of muscle mass and strength that occurs in later life, the result of numerous contributing processes of damage and decline. Researchers...

Sep 19 2020

Daily News

Geroscience and Ovarian Aging

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The geroscience view of the treatment of aging isn’t limited to the reuse of existing drugs that happen to upregulate stress responses in ways that modestly slow aging, but this...