Author: Consultant

May 06 2020

Medicine, Biotech, Research

α-synuclein Aggregation Impairs Autophagy in Brain Tissue

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Age-related neurodegeneration is characterized by the aggregation of a small number of proteins, including α-synuclein, that can become altered in a manner that encourages other molecules of the same protein...

May 05 2020

Medicine, Biotech, Research

What is the Degree of Synergy Between Different Longevity-Associated Mechanisms?

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The degree to which interventions targeting different mechanisms associated with longevity might stack or synergize to produce greater gains is a woefully understudied topic. Study of synergies between treatment approaches...

May 05 2020

Daily News

An Example of a Small Molecule Approach to Telomere Lengthening

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Research groups are eyeing telomere lengthening as a way to improve stem cell function. Telomeres are the caps of repeated DNA sequences at the ends of chromosomes. A little of...

May 05 2020

Daily News

The Ordering of Cholesterol Accumulation and Inflammatory Response in Foam Cell Formation

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The development of atherosclerotic lesions involves the dysfunction of macrophage cells. They are normally responsible for removing lipids from lesions and handing it off to HDL particles to be returned...

May 04 2020

Uncategorized

Gene defects linked to eczema, wheeze and nasal disease among babies

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A link has been discovered between a common gene defect and eczema, nasal blockage and wheeze among babies as young as six months, according to a new study. The research raises new questions about how soon in life these defects...

May 04 2020

Newsletters

Fight Aging! Newsletter, May 4th 2020

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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine....

May 02 2020

Medicine, Biotech, Research

Turning Navitoclax into a PROTAC Senolytic with a Better Safety Profile

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It is interesting to compare today’s open access paper on converting the senolytic drug navitoclax into a PROTAC with recent efforts to improve navitoclax by conjugation with galactose. In both...

May 02 2020

Daily News

Hearing Loss Impairs Synaptic Plasticity and Memory Function in Mice

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The brain makes use of sensory information in order to form memories. Loss of hearing has an impact on the aging brain, as suggested by the correlation between onset of...

May 02 2020

Daily News

Mechanisms of Neurodegeneration Interact to Contribute to Multiple Conditions

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The common neurodegenerative conditions are characterized by the aggregation of a few types of misfolded or otherwise altered proteins, harmful to cell and tissue function. Each form of protein aggregate...

May 01 2020

Self-Experimentation

Notes on Self-Experimentation with Sex Steroid Ablation for Regrowth of the Thymus

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I periodically publish thoughts on self-experiments that seem interesting and relevant to aging. Despite the influence of the quantified self movement, the broader self-experimentation community is largely terrible on matters...