Category: Daily News

Sep 03 2020

Daily News

mTOR in the Cerebrovascular Dysfunction that Contributes to Neurodegenerative Disease

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Aging brings considerable disruption to the vascular system: stiffening of blood vessels; hypertension that damages delicate tissues; a loss of capillary density resulting in reduced delivery of nutrients and oxygen;...

Sep 03 2020

Daily News

Is Age-Related Polyploidy a Beneficial Adaptation to a Damaged Environment?

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Cells with abnormal chromosome counts, a state known as aneuploidy, are considered to be a problem. The evidence suggests that such cells accumulate with age, a form of damage and...

Sep 02 2020

Daily News

Theophylline Produces Accelerated Remyelination in the Central Nervous System of Mice

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The myelin sheathing around axons is necessary for the proper function of nervous system tissue. Demyelinating conditions such as multiple sclerosis, an autoimmune disease in which the immune system attacks...

Sep 02 2020

Daily News

A Better Chondroitinase ABC to Break Down Nerve Tissue Scarring

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Researchers here report on their successful redesign of the chondroitinase ABC enzyme, capable of degrading a form of scarring that forms following nervous system injury. This scarring inhibits regrowth of...

Sep 01 2020

Daily News

Comparing the Genetics of Large and Small Long-Lived Rodents

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Research into the comparative biology of aging seeks to identify important mechanisms determining life span and the progression of aging by comparing different near neighbor species with very different life...

Sep 01 2020

Daily News

The RNAAgeCalc Transcriptional Aging Clock

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Omics data provides a wealth of metrics that correlate with age, quite well in some cases. Weighted combinations of CpG site methylation status, protein levels, and RNA transcript levels have...

Aug 29 2020

Daily News

FOXO3a Suppresses Genomic Instability

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FOXO3a is one of the very few genes for which an association with longevity has been identified in multiple human studies – though one should bear in mind that even...

Aug 29 2020

Daily News

Human Studies Link Calorie Restriction to Improved Cardiometabolic Status

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The data noted here is not news to anyone who has followed calorie restriction research. It is well understood that the practice of calorie restriction is beneficial to long term...

Aug 28 2020

Daily News

Increased Levels of Methylmalonic Acid May Raise the Risk of Metastasis in Older People

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The article here discusses the interesting possibility that comparatively simple differences in circulating factors may be at the root of the higher risk of cancer metastasis in older people. Metastasis...

Aug 28 2020

Daily News

Evidence for Klotho to Act on Life Span in Part via Resistance to Hypertension

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Klotho is a longevity-associated protein. More of it in mice extends life, less of it shortens life. In humans, a number of studies have shown klotho levels to correlate with...