Category: Daily News

Oct 07 2020

Daily News

Dopaminergenic Neurons Transplanted into Mouse Brains Integrate Into Neural Circuits and Improve Parkinson’s Symptoms

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Researchers here demonstrate that human dopaminergenic neurons, the class of cell lost in Parkinson’s disease, can integrate into neural circuits and improve motor function when transplanted into mice. The challenge...

Oct 06 2020

Daily News

Making the Leap from Mice to Humans in the Treatment of Aging

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This commentary makes the point that the development of interventions to slow and reverse aging is moving along at some pace in mice, the field expanding year after year, but...

Oct 06 2020

Daily News

Senolytics as an Arm of Regenerative Medicine for the Elderly

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Senolytic therapies are those that selectively destroy the senescent cells that accumulate in tissues with age. These cells secrete a potent mix of signals that produce chronic inflammation and degrade...

Oct 03 2020

Daily News

Insight into How Loss of Functional TDP-43 Contributes to ALS and Frontotemporal Dementia

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TDP-43 is one of a number of proteins that can misfold in ways that cause neurodegeneration, either via aggregation into solid deposits, or via a diminished amount of functional protein...

Oct 03 2020

Daily News

Fructose Metabolism in Alzheimer’s Disease

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The degree to which Alzheimer’s disease is a lifestyle condition is an interesting question. A good deal of research points to insulin resistance in the brain as important in the...

Oct 02 2020

Daily News

Ketone Body β-hydroxybutyrate Inhibits Inflammation to Reduce Alzheimer’s Pathology in a Mouse Model

by Consultant

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Ketosis is a response to low dietary intake of carbohydrates, and one of the mechanisms by which calorie restriction produces benefits to health and longevity. A ketogenic diet attempts to...

Oct 02 2020

Daily News

Visceral Fat Tissue is the Major Determinant of Mortality Due to Excess Body Weight

by Consultant

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It is the metabolic activity of visceral fat packed around abdominal organs that determines most of the harmful consequences of being overweight, not the subcutaneous fat deposits elsewhere in the...

Oct 01 2020

Daily News

Learning is Damaged Before Memory in the Progression to Clinical Alzheimer’s

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Researchers searching for better ways to assess the early progression towards clinical Alzheimer’s disease have established what looks like a decent way to measure loss of learning capability, a decline...

Oct 01 2020

Daily News

Cellular Senescence as a Mediator of Age-Related COVID-19 Severity

by Consultant

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Wherever we find the intersection of inflammation and aging, important in many age-related conditions, it has become the case that attention is drawn to the role of senescent cells. Senescent...

Sep 30 2020

Daily News

Parkinson’s Disease is Two Distinct Conditions with a Similar Outcome

by Consultant

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Some age-related and other diseases with formal definitions based on symptoms and late stage mechanisms are likely several distinct conditions that happen to converge on a similar end result. This...