Category: Medicine, Biotech, Research

May 26 2020

Medicine, Biotech, Research

Secreted Stem Cell Factors as a Treatment for Male-Pattern Baldness

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Both hair graying and hair loss with age are well researched topics, but there remains considerable uncertainty over which of the possible mechanisms involved are the most relevant, or most...

May 23 2020

Medicine, Biotech, Research

Linking Inflammation and Mitochondrial Dysfunction in Endothelial Tissue

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Today’s open access research implicates an imbalance of mitochondrial dynamics in the direction of too much mitochondrial fission in the age-related chronic inflammation observed in endothelial cells of the cardiovascular...

May 21 2020

Medicine, Biotech, Research

Cellular Senescence in Lung Disease

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Today’s open access paper is a review of what is known of the role of cellular senescence in lung disease. With the development of senolytic therapies that can selectively destroy...

May 20 2020

Medicine, Biotech, Research

SYK Inhibitors as a Novel Class of Senolytics, Mechanisms of Action Yet to Be Determined

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Senescent cells accumulate with age, and this accumulation is an important contributing cause of aging. These errant cells secrete a potent mix of signal molecules that spur chronic inflammation and...

May 19 2020

Medicine, Biotech, Research

Follistatin Gene Therapy Doubles Muscle Mass in Mice

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Follistatin is an inhibitor of myostatin. Blocking myostatin activity enhances muscle growth, with accompanying beneficial side-effects such as a loss of excess fat tissue. This is well proven. There are...

May 16 2020

Medicine, Biotech, Research

On Nutraceutical Senolytics

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Nutraceuticals are compounds derived from foods, usually plants. In principle one can find useful therapies in the natural world, taking the approach of identifying interesting molecules and refining them to...

May 15 2020

Medicine, Biotech, Research

Transplanting Gut Microbes from Old Rats to Young Rats Produces Inflammation and Cognitive Decline

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Today’s open access paper is interesting on two counts. Firstly as one of a number of studies in recent years examining the effects of age-related changes in the gut microbiome...

May 14 2020

Medicine, Biotech, Research

A Biomarker of Aging Based on Protein Glycosylation Patterns

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Today I’ll note the development of a commercial aging clock based on glycosylation patterns of immunoglobulin G, a marker for the inflammatory status of the immune system, by startup biotech...

May 13 2020

Medicine, Biotech, Research

Mitochondrial Complex I Subunit Protein Abundance Correlates with Mammalian Species Longevity

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The gerontology community is most interested in identifying and quantifying the mechanisms that determine species longevity. Why do different mammalian species have radically different life spans, from the year of...

May 12 2020

Medicine, Biotech, Research

Advocating for Senolytics to Prevent Accelerated Aging Resulting from Cancer Treatment

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Chemotherapy and radiotherapy remain the presently dominant forms of cancer treatment. Immunotherapies are making slow inroads, but remain a minority of all treatments. Both chemotherapy and radiotherapy kill cells and...