Category: Daily News

Sep 18 2020

Daily News

Lowered Body Temperature is Important in the Beneficial Calorie Restriction Response

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Calorie restriction lowers body temperature in mammals, but most research on how reduced calorie intake produces benefits to long-term health and longevity has focused on nutrient sensing as the primary...

Sep 18 2020

Daily News

Metformin Found to Reduce Liver Inflammation

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Metformin produces a modest and unreliable extension of life in animal models, and human data shows a small increase in life span in diabetic patients. This is thought to work...

Sep 17 2020

Daily News

Targeting Inflammatory Microglia in the Treatment of Neurodegenerative Disease

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The immune cells of the central nervous system are distinct from those of the rest of the body. Innate immune cells such as microglia become increasingly inflammatory with advancing age,...

Sep 17 2020

Daily News

The Aging of Macrophages Impairs Peripheral Nerve Regeneration

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Macrophages of the innate immune system, cells derived from monocytes, are involved in many processes in tissue beyond merely hunting down invading pathogens. They are also important to the processes...

Sep 16 2020

Daily News

Using Direct Conversion of Cells to Investigate the Behavior of Aging Tissues

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The process of reprogramming used to produce induced pluripotent stem cells erases many of the marks of aging in cells taken from old tissues, such as epigenetic changes and declining...

Sep 16 2020

Daily News

Upregulation of Unacetylated Ghrelin Slows Age-Related Muscle Loss in Mice

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Ghrelin is best known for its role in the mechanisms of hunger, but it has two different forms, only one of which induces hunger. Both forms are known to affect...

Sep 15 2020

Daily News

Increased Insulin Receptor Expression Improves Memory in Old Rats

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This is a interesting example of modulating the metabolism of the aging brain in order to improve its function, without any attempt to address the underlying cell and tissue damage...

Sep 15 2020

Daily News

Evidence for Familial Longevity to be Largely Cultural Rather than Genetic

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It is certainly possible that a small number of people have mutations or genetic variants that confer notable longevity. The small lineage exhibiting a PAI-1 loss of function mutation springs...

Sep 12 2020

Daily News

Greater Fitness Correlates with Lower White Matter Hyperintensity Volume in the Aging Brain

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White matter hyperintensities in the brain are small areas of damage most likely produced by the rupture or other loss of integrity of tiny blood vessels. In effect they are...

Sep 12 2020

Daily News

Dysfunction of the Blood-Brain Barrier as an Early Stage in the Progression to Dementia

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The blood-brain barrier is a lining of specialized cells that surrounds blood vessels passing through the brain. The barrier permits only certain molecules and cells to pass, isolating the tissue...